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Clinical nephrology · pathways · guidelines · handbook
Nephron Clinical Reference

Practical nephrology for clinical decision-making, training and specialist review.

A structured reference built on two layers: problem-based clinical manifestations for rapid decisions, and guideline-derived summaries as the evidence layer.
Start with a clinical pathway Browse guidelines
Problem-basedStart from proteinuria, haematuria, AKI, CKD, TMA or electrolyte disorders — the way patients present.
Guideline-groundedKDIGO, ESC, Dutch and international specialty guidance translated into practical summaries for clinic use.
Specialist formatBuilt for outpatient and inpatient consults, on-call decisions and structured teaching across all training levels.

Clinical manifestations

Start here for rapid triage, diagnostic structure and practical next steps. Each page answers: what do I do now?

Proteinuria Haematuria Nephrotic syndrome Glomerulonephritis Thrombotic microangiopathy Acute kidney injury Chronic kidney disease Electrolytes & acid-base Hypertension in CKD Kidney biopsy interpretation

Guideline domains

The source layer behind clinical decisions. Organised by domain — use these pages to check what the evidence and guidelines say.

CKD

Chronic kidney disease

Classification, progression risk, anaemia, CKD-MBD, nutrition and longitudinal care.

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CV

Cardiovascular & hypertension

Blood pressure, cardiovascular risk, heart failure and cardiorenal management.

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DM

Diabetes & metabolism

Diabetes in CKD, SGLT2 inhibitors, GLP-1 receptor agonists, finerenone and lipids.

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GN

Glomerular & immunology

Glomerular disease, biopsy, IgAN, lupus nephritis, AAV, MN, MCD and FSGS.

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DNA

Genetic & cystic kidney disease

ADPKD, Alport syndrome, cystic kidney disease and genetic testing guidance.

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PAL

Conservative & palliative care

Shared decision-making, symptom control and conservative kidney management.

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MBD

Bone, mineral & endocrine

CKD-MBD, PTH, phosphate, osteoporosis and fracture prevention in kidney disease.

Open domain →

How this site is structured

Clinical manifestations answer "what do I do now?" — they are the rapid-access layer. Guideline pages answer "what source supports this?" — they are the evidence layer. For deep background and pathophysiological context, a clinical handbook section will be added in a future update.